|
KMID : 0620920180500030016
|
|
Experimental & Molecular Medicine
2018 Volume.50 No. 3 p.16 ~ p.16
|
|
|
Estrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression
|
|
Sun Yang
Qin Zhen
Wan Jing-Jing
Wang Peng-Yuan
Yang Yi-Li
Yu Jian-Guang
Hu Bo-Han
Su Ding-Feng
Luo Zhu-Min
Liu Xia
|
|
|
Abstract
|
|
|
|
Gender differences in fatigue manifest as females being more prone to feel exhaustion and having lower muscle endurance. However, the mechanisms of these effects remain unclear. We investigated whether orosomucoid, an endogenous anti-fatigue protein that enhances muscle endurance, is involved in this regulation. Female rats exhibited lower muscle endurance, and this gender difference disappeared in orosomucoid-1-deficient mice. Female rats also exhibited weaker orosomucoid induction in serum, liver and muscle in response to fatigue compared with male rats. Ovariectomy elevated orosomucoid levels and increased swimming time, and estrogen replenishment reversed these effects. Exogenous estrogen treatment in male and female mice produced opposite effects. Estrogen decreased orosomucoid expression and its promoter activity in C2C12 muscle and Chang liver cells in vitro, and estrogen receptor or p38 mitogen-activated protein kinase blockade abolished this effect. Therefore, estrogen negatively regulates orosomucoid expression that is responsible for the weaker muscle endurance in females.
|
|
|
KEYWORD
|
|
|
Cell signalling, Mechanisms of disease
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|